外周血细胞计数在PGI-DLBCL患者预后评估中的价值Value of peripheral blood cell count in prognosis evaluation of patients with PGI-DLBCL
赵盼;于泳;王亚非;赵智刚;张翼鷟;王晓芳;
摘要(Abstract)：
目的探讨外周血细胞计数在原发胃肠道弥漫大B细胞淋巴瘤(PGI-DLBCL)患者预后评估中的价值。方法回顾性分析2009年3月~2015年5月经病理检查明确诊断为PGI-DLBCL患者的临床资料,分析其绝对淋巴细胞计数(ALC)、绝对单核细胞计数(AMC)、淋巴细胞计数与单核细胞计数比值(LMR)及PLT计数与淋巴细胞计数比值(PLR)对PGI-DLBCL患者5年总生存率、5年无疾病进展生存率的影响。将168例患者根据国际预后指数(IPI及aa IPI)评分分为低危、低中危、中高危、高危组,根据LMR联合IPI或aa IPI评分分为3组,其中LMR≥2.5、低危患者为预后良好组,LMR<2.5、高危患者为预后极差组,其余为预后一般组。比较各组的总生存率、无疾病进展生存率。结果患者中位年龄55岁(12~90岁),中位随访时间25个月(8~79个月)。单因素分析提示,ALC、AMC、LMR、PLR与5年总生存率、5年无疾病进展生存率有关(P均<0.05)。多因素分析提示,5年无疾病进展生存率与ALC、LMR、乳酸脱氢酶有关(P均<0.05),5年总生存率与年龄、LMR有关(P均<0.05)。低危、低中危、中高危、高危组中,中高危与高危组5年总生存率和无疾病进展生存率差异无统计学意义(5年总生存率分别为32.0%、23.8%;5年无疾病进展生存率分别为20.0%、23.8%;P均>0.05)。预后良好组、预后一般组、预后极差组5年总生存率分别为82.8%、60.0%、14.3%,5年无疾病进展生存率分别为79.3%、53.8%、14.8%。3组及组间两两比较,P均<0.05。结论初诊时外周血细胞计数对评估PGI-DLBCL患者的预后有重要价值。LMR联合IPI评分有助于PGI-DLBCL患者发病初期更好地进行危险分层。
关键词(KeyWords)： 原发胃肠道弥漫大B细胞淋巴瘤;绝对淋巴细胞计数;绝对单核细胞计数;血小板计数;预后
基金项目(Foundation): 国家自然科学基金资助项目(81272562)
作者(Author): 赵盼;于泳;王亚非;赵智刚;张翼鷟;王晓芳;
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