SiRNA在肝纤维化基因治疗中的应用进展
罗媛元;王丽娜;殷子斐;
摘要(Abstract)：
肝纤维化是各种慢性致病因素作用于肝脏,引起组织损伤修复的病理反应,是多种肝脏疾病发展至肝硬化的必经阶段。小干扰RNA(siRNA)能够高效、特异地破坏mRNA的完整性,抑制疾病相关基因的表达,在基因治疗领域有广阔应用前景。目前研究表明,siRNA能有效地从基因水平进行调控,抑制肝星状细胞的活化与增殖,增加细胞外基质的降解,可成为肝纤维化治疗的有效手段。
关键词(KeyWords)： 肝纤维化;肝星状细胞;小干扰RNA;基因治疗
基金项目(Foundation): 国家自然科学基金资助项目(81303112)
作者(Author): 罗媛元;王丽娜;殷子斐;
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DOI:
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