昆布提取物J201对大鼠肺纤维化的抑制作用
王丽娜;蒋捍东;
摘要(Abstract)：
向W istar大鼠气管内灌注博莱霉素(BLM)诱导肺纤维化,治疗1、2组分别每日给予J201 25、50m g/kg灌胃。发现治疗2组肺泡炎程度及Ⅰ型胶原、转化生长因子1β(TGF-1β)、血小板源性生长因子-B(PDGF-B)蛋白表达水平均显著低于纤维化模型组。可见昆布提取物J201能减轻BLM诱导的大鼠肺纤维化,其效果与剂量有关。
关键词(KeyWords)： 昆布提取物,J201;肺纤维化;博莱霉素;转化生长因子β
基金项目(Foundation): 山东省科学技术发展计划项目(2002BB1CKA2)
作者(Author): 王丽娜;蒋捍东;
Email:
DOI:
参考文献(References)：
- [1]Szap iel SV,E lson NA,Fu lm er JD,et a l.B leom ycin inducedin terstitia l pu lm onary d isease in the nude,athym ic m ouse[J].Am R ev R ep D is,1979,120(4):893-899.
- [2]Y am ash ita Y,N akogon i KA,T aked T,et a l.E ffect of heparinof pu lm onary fibrob lasts and vascu lar cells[J].Thorax,1992,47(8):643-649.
- [3]A zum a A,L i Y J,A be S,et a l.In terferon-beta inh ib its b leom y-cin-induced lung fibrosis by decreasing transform ing grow thfactor-beta and throm bospond in[J].Am J R esp ir C ellM o l B io l,2005,32(2):93-98.
- [4]Sasak iM,K ash im aM,Ito T,et a l.E ffect of heparin and relatedg lycosam inog lycan on PDGF-induced lung fibrob last pro liferati-on,chem otactic response and m atrix m eta lloprote inases activ ity[J].M ed iators In flamm,2000,9(2):85-91.