2型糖尿病大鼠HbA_(1c)与RCD的相关性
周慧敏;刘璠;张庆富;杨爱格;韩旭;王丽娜;
摘要(Abstract)：
目的探讨2型糖尿病(T2DM)大鼠糖化血红蛋白(HbA1c)与红细胞变形能力(RCD)的相关性。方法 Wistar大鼠148只,随机选6只作为基础对照,检测其空腹胰岛素(FINS)、红细胞刚性指数(IR)和HbA1c;其余分为正常组42只,链脲佐菌素(STZ)-1组及STZ-2组各50只,建立DM大鼠模型;分组后4、8周及建模后0、4、8、12、16周检测各组FINS、IR和HbA1c,以IR表示RCD。结果与正常组比较,DM大鼠随着HbA1c升高,IR逐渐升高(P<0.01);IR与HbA1c呈正相关(r=0.970 2,P<0.01)。结论严格控制HbA1c、早期改善RCD,有助于预防DM大鼠血栓性并发症的发生及发展。
关键词(KeyWords)： 糖尿病,2型;大鼠;糖化血红蛋白;红细胞变形能力
基金项目(Foundation): 河北省科技攻关重大项目(07276103D)
作者(Author): 周慧敏;刘璠;张庆富;杨爱格;韩旭;王丽娜;
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参考文献(References)：
- [1]Tsukada K,Sekizuka E,Oshio C,et al.Direct measurement of e-rythrocyte deformability in diabetes mellitus with a transparent micro-channel capillary model and high-speed video camera system[J].Microvasc Res,2001,61(3):231-239.
- [2]Symeonidis A,Athanassiou G,Psiroyannis A,et al.Impairment oferythrocyte viscoelasticity is correlated with levels of glycosylatedhaemoglobin in diabetic patients[J].Clin Lab Haematol,2001,23(2):103-109.
- [3]Diamantopoulos EJ,Kittas C,Charitos D,et al.Impaired erythro-cyte deformability precedes vascular changes in experimental diabe-tes mellitus[J].Horm Metab Res,2004,36(3):142-147.
- [4]Brown CD,Zhao ZH,Thomas LL,et al.Effects of erythropoietinand aminoguanidine on red blood cell deformability in diabeticazotemic and uremic patients[J].Am J Kidney Dis,2001,38(6):1414-1420.
- [5]Babu N.Influence of hypercholesterolemia on deformability andshape parameters of erythrocytes in hyperglycemic subjects[J].ClinHemorheol Microcirc,2009,41(3):169-177.
- [6]Schiekofer S,Galasso G,Sato K,et al.Impaired revascularizationin a mouse model of type 2 diabetes is associated with dysregulationof a complex angiogenic-regulatory network[J].Arterioscler ThrombVasc Biol,2005,25(8):1603-1609.
- [7]Negrean V,Suciu I,Sampelean D,et al.Rheological changes indiabetic microangiopathy[J].Rom J Intern Med,2004,42(2):407-413.
- [8]Petropoulos IK,Margetis PI,Antonelou MH,et al.Structural alter-ations of the erythrocyte membrane proteins in diabetic retinopathy[J].Graefes Arch Clin Exp Ophthalmol,2007,245(8):1179-1188.