脑损伤早产儿血清25-羟维生素D水平变化及其与IL-17、IL-10水平的相关性
李明磊;孟令建;杜薇薇;王军;
摘要(Abstract)：
目的 观察脑损伤早产儿血清25-羟维生素D[25-(OH)D]水平的变化情况，探讨其与炎症反应的关系。方法 选择生后24 h内入住NICU的53例早产儿，其中发生脑损伤24例（观察组），未发生脑损伤29例（对照组）。采集两组生后第1、7、14天桡动脉血，采用ELISA法检测血清25-(OH)D及IL-17、IL-10水平，分析血清25-(OH)D与IL-17、IL-10的相关性。结果 两组血清25-(OH)D水平在生后第1、7天较低，第14天逐渐升高，观察组各时间点25-(OH)D水平均低于对照组（P均<0.05）。观察组第7天IL-17水平高于第1、14天（P均<0.05），第14天与第1天差异无统计学意义（P>0.05），观察组各时间点IL-17水平均高于对照组（P均<0.05）。观察组第14天IL-10水平高于第1、7天（P均<0.05），对照组IL-10水平第7天低于第1天、第14天低于第7天（P均<0.05）。观察组血清25-(OH)D水平在生后第1、7、14天与IL-17水平均呈负相关（P均<0.05），在第1、7天与IL-10水平呈正相关（P均<0.05）。结论 脑损伤早产儿生后各时间点血清25-(OH)D水平均较低，其水平变化与IL-17、IL-10水平相关；补充维生素D或可抑制脑损伤后的炎症反应。
关键词(KeyWords)： 早产儿;脑损伤;25-羟维生素D;白细胞介素17;白细胞介素10
基金项目(Foundation): 江苏省妇幼健康科研项目（F201743）
作者(Authors): 李明磊;孟令建;杜薇薇;王军;
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