子痫前期孕妇孕早期、孕中期血清25(OH)D_3水平变化及其意义
朱飞龙;陈慧芬;张军;吴瑛婷;刘媛;
摘要(Abstract)：
目的观察子痫前期(PE)孕妇不同孕期血清25-羟基维生素D[25(OH)D_3]水平变化,并探讨其意义。方法选取重度子痫前期(SPE)孕妇335例(重度组)、非重度子痫前期孕妇127例(非重度组),另选500例健康体检孕妇作对照(对照组),比较各组孕早期(14周)、孕中期(28周)血清25(OH)D_3水平及25(OH)D_3缺乏情况。结果与对照组比较,重度组孕早期、孕中期25(OH)D_3水平及非重度组孕中期25(OH)D_3水平降低(P均<0.05);与同组孕早期比较,重度组孕中期25(OH)D_3水平升高,非重度组孕中期25(OH)D_3水平降低(P均<0.05)。与对照组比较,重度组和非重度组孕早期、孕中期25(OH)D_3缺乏率高(P均<0.05)。结论 SPE孕妇孕早期、孕中期血清25(OH)D_3水平降低,非重度子痫前期孕妇孕中期血清25(OH)D_3水平降低,血清25(OH)D_3水平与PE的发生发展密切相关,其可作为PE病情严重程度的预测指标。
关键词(KeyWords)： 子痫前期;重度子痫前期;维生素D;25-羟基维生素D
基金项目(Foundation):
作者(Author): 朱飞龙;陈慧芬;张军;吴瑛婷;刘媛;
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