李欢;熊静;杨树龙;洪芬芳;

• 1:南昌大学

摘要(Abstract)：

在肝脏缺血再灌注损伤导致的细胞凋亡过程中,线粒体通路和氧化应激是两条非常重要的机制。当肝脏发生缺血再灌注时,线粒体通透性转换孔的开放、细胞凋亡相关蛋白的释放以及B淋巴细胞瘤-2基因家族蛋白的调控作用共同组成线粒体通路,导致细胞凋亡;氧化应激则通过脂质过氧化、内质网应激、氧化应激调节分子表达变化等途径在肝脏缺血再灌注损伤细胞凋亡中发挥作用。

关键词(KeyWords)： 线粒体通路;氧化应激;肝脏缺血再灌注损伤;肝细胞凋亡

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81660151、81260504、81660751);; 江西省重点研发计划项目(20161BBG70067);; 江西省自然科学基金项目(20171BAB205085)

作者(Authors): 李欢;熊静;杨树龙;洪芬芳;

参考文献(References)：

• [1]朱晋锋.氧化应激与肝脏缺血再灌注损伤的研究进展[J].医学临床研究,2010,27(4):737-739.
• [2]Grossini E,Pollesello P,Bellofatto K,et al. Protective effects elicited by levosimendan against liver ischemia/reperfusion injury in anesthetized rats[J]. Liver Transpl,2014,20(3):361-375.
• [3]Fu H,Chen H,Wang C,et al. Flurbiprofen,a cyclooxygenase inhibitor,protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3βsignaling and mitochondrial permeability transition[J]. Mol Med,2012,18(1):1128-1135.
• [4]Cai L,Li Y,Zhang Q,et al. Salidroside protects rat liver against ischemia/reperfusion injury by regulating the GSK-3beta/Nrf2-dependent antioxidant response and mitochondrial permeability transition[J]. Eur J Pharmacol,2017,806:32-42.
• [5]Khader A,Yang WL,Godwin A,et al. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy[J]. Crit Care Med,2016,44(8):651-663.
• [6]Zhang Q,Fu H,Zhang H,et al. Hydrogen sulfide preconditioning protects rat liver against ischemia/reperfusion injury by activating Akt-GSK-3 I2signaling and inhibiting mitochondrial permeability transition[J]. PLo S One,2013,8(9):e74422.
• [7]Lin HC,Liu SY,Yen EY,et al. microRNA-183 Mediates Protective Postconditioning of the Liver by Repressing Apaf-1[J]. Antioxid Redox Signal,2017,26(11):583-597.
• [8] Strifler G,Tuboly E,Szél E,et al. Inhaled Methane Limits the Mitochondrial Electron Transport Chain Dysfunction during Experimental Liver Ischemia-Reperfusion Injury[J]. PLo S One,2016,11(1):e146363.
• [9]Yang J,Sun H,Guan R,et al. Hepatocellular Protein Profiles After Hepatic Ischemia/Reperfusion Injury With or Without Octreotide Preconditioning in a Rabbit Model[J]. Transplant Proc,2014,46(10):3282-3288.
• [10]Yang J,Sun H,Takacs P,et al. The effect of octreotide on hepatic ischemia-reperfusion injury in a rabbit model[J]. Transplant Proc,2013,45(6):2433-2438.
• [11]Miyamoto H,Doita M,Nishida K,et al. Effects of cyclic mechanical stress on the production of inflammatory agents by nucleus pulposus and anulus fibrosus derived cells in vitro[J]. Spine,2006,31(1):4.
• [12]Kawamura E,Yamanaka N,Okamoto E,et al. Response of plasma and tissue endothelin-1 to liver ischemia and its implication in ischemia-reperfusion injury[J]. Hepatology,1995,21(4):1138-1143.
• [13]Chang YY,Liu YC,Kuo YH,et al. Effects of antrosterol from Antrodia camphorata submerged whole broth on lipid homeostasis,antioxidation,alcohol clearance,and anti-inflammation in livers of chronic-alcohol fed mice[J]. J Ethnopharmacol,2017,202:200.
• [14]顾达民,陈宇,张小宝,等.氯胺酮对脂多糖诱导的大鼠肺泡巨噬细胞氧化应激的影响[J].实用临床医药杂志,2008,12(12):1-2.
• [15]Xu Z,Yu J,Wu J,et al. The Effects of Two Anesthetics,Propofol and Sevoflurane,on Liver Ischemia/Reperfusion Injury[J]. Cell Physiol Biochem,2016,38(4):1631-1642.
• [16] Suo L,Kang K,Wang X,et al. Carvacrol alleviates ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats[J].PLo S One,2014,9(8):e104043.
• [17]Cahova M,Palenickova E,Dankova H,et al. Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation.[J]. Am J Physiol Gastrointest Liver Physiol,2015,309(2):G100-111.
• [18]Deniaud A,Dein OSE,Maillier E,et al. Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis[J]. Oncogene,2008,27(3):285-299.
• [19]Sun Y,Pu LY,Lu L,et al. N-acetylcysteine attenuates reactiveoxygen-speciesmediated endoplasmic reticulum stress during liver ischemia-reperfusion injury[J]. World J Gastroenterol, 2014(41):15289-15298.
• [20]Wang C,Kan C,Xia Y,et al. N-Acetylcysteine Attenuates Ischemia-Reperfusion-Induced Apoptosis and Autophagy in Mouse Liver via Regulation of the ROS/JNK/Bcl-2 Pathway[J]. PLo S One,2014,9(9):e108855.
• [21]Xu ZC,Yin J,Zhou B,et al. Grape seed proanthocyanidin protects liver againstischemia/reperfusion injury by attenuating endoplasmicreticulum stress[J]. World J Gastroenterol,2015,21(24):7468-7477.
• [22]Tao J,Shen X,Ai Y,et al. Tea polyphenols protect against ischemia/reperfusion-induced liver injury in mice through anti-oxidative and anti-apoptotic properties[J]. Exp Ther Med,2016,12(5):3433-3439.
• [23]Xu F,Dai CL,Peng SL,et al. Preconditioning with glutamine protects against ischemia/reperfusion-induced hepatic injury in rats with obstructive jaundice[J]. Pharmacology,2014,93(3-4):155-165.
• [24] Seif AA,Abdelwahed DM. Vitamin D ameliorates hepatic ischemic/reperfusion injury in rats[J]. J Physiol Biochem,2014,70(3):659-666.
• [25]Huang X,Qin J,Lu S. Magnesium isoglycyrrhizinate protects hepatic L02 cells from ischemia/reperfusion induced injury[J]. Int J Clin Exp Pathol,2014,7(8):4755-4764.
• [26]Fang J,Qin H,Seki T,et al. Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1:results from a rat hepatic ischemia/reperfusion injury model[J]. J Pharmacol Exp Ther,2011,339(3):779-789.
• [27]Jadeja RN,Upadhyay KK,Devkar RV,et al. Naturally Occurring Nrf2 Activators:Potential in Treatment of Liver Injury[J]. Oxid Med Cell Longev,2016,2016:3453926.
• [28]Ben MI,Mouchel Y,Pajaud J,et al. Pretreatment with mangafodipir improves liver graft tolerance to ischemia/reperfusion injury in rat[J]. PLo S One,2012,7(11):e50235.
• [29]Chi X,Zhang R,Shen N,et al. Sulforaphane reduces apoptosis and oncosis along with protecting liver injury-induced ischemic reperfusion by activating the Nrf2/ARE pathway[J]. Hepatol Int,2015,9(2):321-329.
• [30]Shimada S,Fukai M,Wakayama K,et al. Hydrogen sulfide augments survival signals in warm ischemia and reperfusion of the mouse liver[J]. Surg Today,2015,45(7):892-903.