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年龄相关B淋巴细胞（ABCs）是一类以CD11c、T-bet高表达及CD21、CXCR5低表达为主要表型特征的B淋巴细胞亚群，近年来被认为是连接免疫衰老、慢性炎症与自身免疫反应的重要细胞群。在不同疾病背景下，ABCs既可被视为衰老或慢性炎症环境中形成的应激性B淋巴细胞状态，也可能代表在自身免疫环境中被持续选择和扩增的致病性B淋巴细胞亚群。目前，ABCs在系统性红斑狼疮、类风湿关节炎、原发性干燥综合征及多发性硬化等自身免疫性疾病中的作用逐渐受到关注，与疾病活动、自身抗体产生、器官损伤及治疗反应相关，是自身免疫性疾病发病机制研究和精准治疗探索中值得关注的B淋巴细胞亚群。
Abstract：Age-associated B cells(ABCs) are a B-cell subset characterized primarily by high expression of CD11c and T-bet and low expression of CD21 and CXCR5.In recent years, ABCs have been recognized as an important cell population linking immunosenescence, chronic inflammation, and autoimmune responses.Depending on the disease context, ABCs may be regarded either as a stress-associated B-cell state arising in aging or chronic inflammatory environments or as a pathogenic B-cell subset that is continuously selected and expanded under autoimmune conditions.Increasing attention has been paid to the roles of ABCs in autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, primary Sjögren's syndrome, and multiple sclerosis.ABCs have been associated with disease activity, autoantibody production, organ damage, and treatment response, making them an important B-cell subset in studies of autoimmune pathogenesis and the development of precision therapies.
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基本信息:
中图分类号:R593.2
引用信息:
[1]谢傲,宋娟娟,赵雅境,等.年龄相关B淋巴细胞在自身免疫性疾病中的作用研究进展[J].山东医药,2026,66(07):155-159.
基金信息:
国家自然科学基金面上项目（82570171）
2026-07-25
2026-07-25