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目的：分析人博卡病毒（HBoV）与人鼻病毒（HRV）呼吸道混合感染患儿临床特征，为临床诊治提供依据。方法回顾性纳入急性呼吸道感染患儿120例，其中单一HBoV感染、单一HRV感染、混合感染各40例。收集并比较单一病毒感染与混合感染患儿的基本资料、实验室指标、影像学表现。结果混合感染患儿喘息比例高于单一HBoV感染患儿（P＜0.05），二者性别、年龄、发热、病程、住院时间比较差异无统计学意义（P均＞0.05）。混合感染患儿发热比例高于单一HRV感染患儿（P＜0.05），二者性别、年龄、喘息、病程、住院时间比较差异无统计学意义（P均＞0.05）。混合感染与单一HBoV感染患儿实验室指标比较差异无统计学意义（P均＞0.05）。混合感染患儿C反应蛋白（CRP）、免疫球蛋白G（IgG）水平高于单一HRV感染患儿（P均<0.05），肌酸激酶同工酶MB（CK-MB）水平低于单一HRV感染患儿（P＜0.05），二者其他实验室指标比较差异无统计学意义（P均＞0.05）。单一感染与混合感染患儿影像学表现比较差异无统计学意义（P均＞0.05）。结论 HRV混合HBoV感染可诱发更强的炎症及免疫应答，加重发热症状，且增加HRV感染相关的心肌损伤风险与喘息发作。
Abstract：Objective: To analyze the clinical characteristics of children with respiratory co-infections involving human bocavirus (HBoV) and human rhinovirus (HRV)， providing evidence for clinical diagnosis and treatment. Methods: A retrospective study included 120 children with acute respiratory infections， comprising 40 cases each of single HBoV infection， single HRV infection， and co-infection. Basic demographic data， laboratory parameters， and radiological findings were collected and compared between children with single viral infections and those with co-infections. Results: The proportion of wheezing in co-infected children was higher than in those with single HBoV infection (P < 0.05). No significant differences were observed between these two groups regarding gender， age， fever， disease duration， or hospitalization length (all P > 0.05). The proportion of fever in co-infected children was higher than in those with single HRV infection (P < 0.05)， while no significant differences were found in gender， age， wheezing， disease duration， or hospitalization time (all P > 0.05). There were no statistically significant differences in laboratory parameters between co-infected and single HBoV-infected children (all P > 0.05). Co-infected children had higher levels of C-reactive protein (CRP)， lower levels of creatine kinase-MB (CK-MB)， and higher immunoglobulin G (IgG) levels compared to those with single HRV infection (all P < 0.05); however， no significant differences were noted in other laboratory parameters (all P > 0.05). Radiological findings showed no significant differences between single and co-infected children (all P > 0.05). Conclusion: HRV co-infection with HBoV may trigger stronger inflammatory and immune responses， exacerbating fever symptoms; attention should be paid to the risk of myocardial injury associated with HRV infection and the occurrence of wheezing episodes.
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基本信息:
中图分类号:R725.6
引用信息:
[1]席少婷,董程程,周亮.40例人博卡病毒与人鼻病毒呼吸道混合感染患儿临床特征分析[J].山东医药().
基金信息:
河北省医学科学研究课题计划（20231168）
2026-08-05
2026-08-05
2026-08-05