山东医药

目的 基于磁共振（MRI）扩散张量成像（DTI）分析肝气郁结型青年抑郁症患者脑白质微结构的完整性。方法 肝气郁结型青年抑郁症患者28例记为抑郁组，同期本院体检或招募的20例健康志愿者作为对照组，两组受试者均接受头颅MRI及DTI扫描，测算各脑区白质各向异性分数（FA）值以评价脑白质微结构的完整性。采用Spearman相关分析法分析抑郁组受试者不同脑区FA值与HAMD-17评分的相关性。结果 与对照组相比，抑郁组受试者右侧额上回、右侧顶下小叶、右侧扣带回、右侧丘脑、左侧额中回、胼胝体膝部及胼胝体体部等脑区白质FA值显著降低（P均<0.05）。抑郁组受试者右侧额上回、左侧额中回FA值与HAMD-17评分呈负相关关系（r分别为-0.325、-0.346,P均<0.05）。结论 肝气郁结型青年抑郁症患者存在广泛的脑白质微结构完整性受损。

Objective To analyze the integrity of white matter microstructure in young patients with liver-qi stagnation type depression based on magnetic resonance imaging(MRI) diffusion tensor imaging(DTI). Methods Twentyeight young patients with liver-qi stagnation type depression were enrolled as the depression group, and 20 healthy volunteers who underwent physical examination or recruitment in our hospital were selected as the control group. The subjects of both groups underwent head MRI and DTI scans, and the fraction anisotropy(FA) of white matter in each brain region was calculated to evaluate the integrity of white matter microstructure. Using Spearman correlation analysis to analyze the correlation between FA values in different brain regions and HAMD-17 scores in subjects with depression. Results Compared with the control group, the FA values of white matter in brain regions such as the right superior frontal gyrus, right inferior parietal lobule, right cingulate gyrus, right thalamus, left middle frontal gyrus, knee and body of corpus callosum were significantly reduced in the depression group(all P<0. 05). The FA values of the right upper frontal gyrus and left middle frontal gyrus in the depression group were negatively correlated with HAMD-17 scores(r=-0. 325,-0. 346, both P<0. 05). Conclusion Young patients with liver-qi stagnation type depression exhibit extensive damage to the integrity of white matter microstructure in the brain.